Dr. Marie-Joelle VIROLLE | Antibiotics | Lifetime achievement Award

Research Director at University Paris Saclay, France

Marie-Joëlle Virolle is an accomplished CNRS Research Director with an extensive background in microbiology, specifically focusing on the energetic metabolism of Streptomyces. Her academic journey, which began with a PhD at the John Innes Institute, has led to a distinguished career at the Institute of Integrative Biology of the Cell (I2BC) in France. With over 50 publications and numerous research projects funded by prestigious organizations, her work has significantly impacted the field of microbiology. Virolle’s leadership in various scientific collaborations and editorial responsibilities further underscores her expertise and influence in the scientific community.

 

📝professional profile

Scopus Profile

🎓Educational Details:

Dr. Marie-Joëlle Virolle pursued her advanced education in the field of microbiology, earning her PhD between 1984 and 1987 at the prestigious John Innes Institute in Norwich, UK. Under the mentorship of Dr. MJ Bibb, her doctoral research focused on the cloning, characterization, and preliminary study of the regulation of gene expression in Streptomyces species. Her PhD was funded through a CIFRE contract with the Roussel Uclaf company, highlighting the applied nature and industrial relevance of her work. This rigorous academic foundation laid the groundwork for Dr. Virolle’s distinguished career in microbiological research, particularly in the study of Streptomyces and its metabolic processes.

👨‍🏫Experience

Dr. Marie-Joëlle Virolle has had a distinguished career in microbiology, particularly in the study of Streptomyces and its energetic metabolism. She currently holds the prestigious position of CNRS Research Director and leads the “Energetic Metabolism of Streptomyces” group at the Institute of Integrative Biology of the Cell (I2BC) at the University of Paris-Sud. Dr. Virolle’s research journey began with a PhD at the John Innes Institute in Norwich, UK, where she focused on the cloning, characterization, and regulatory study of genes from Streptomyces species. Over the years, she has secured and managed numerous high-profile research grants from international organizations, demonstrating her ability to attract significant funding for her innovative work.

Her role as a research director has involved not only leading her research team but also establishing and nurturing collaborations across various local, national, and international institutions. These partnerships have extended to countries like China, Egypt, Morocco, and the USA, reflecting her global influence and the broad applicability of her research. Additionally, Dr. Virolle has taken on several administrative and advisory roles, such as serving on the steering committee of the European ACTINOGEN program and being an elected member of the Research Council of the University Paris-Sud.

Awards and Honors :

Dr. Marie-Joëlle Virolle has garnered significant recognition for her pioneering research in microbiology, particularly in the study of the energetic metabolism of Streptomyces. Throughout her illustrious career, she has received multiple awards and honors that reflect her contributions to science and her leadership in the field. Her expertise has been acknowledged through prestigious grants from international programs such as the European Program ACTINOGEN, the Franco-Moroccan PAI, and the Franco-Chinese NSFC Program. Additionally, Dr. Virolle’s role as an editor for leading scientific journals, including Scientific Reports, Frontiers in Microbiology, and PLOS ONE, underscores the high regard in which she is held by her peers. These editorial positions, combined with her prolific publication record and her successful leadership of the “Energetic Metabolism of Streptomyces” group at I2BC, have solidified her reputation as a leading figure in the field of microbiology. Her numerous awards and honors serve as a testament to her enduring impact on the scientific community and her unwavering dedication to advancing knowledge in her area of expertise.

Research Focus:

Dr. Marie-Joëlle Virolle’s research primarily focuses on the metabolic processes and regulatory mechanisms of Streptomyces, a genus of bacteria known for its complex secondary metabolism, which includes the production of antibiotics and other bioactive compounds. Her work delves into understanding the energetic metabolism of Streptomyces, exploring how these microorganisms manage energy resources during growth and production phases. By studying the regulatory networks that control gene expression related to energy metabolism, Dr. Virolle aims to uncover the underlying principles that drive the biosynthesis of valuable metabolites. Her research not only contributes to fundamental microbiological knowledge but also has practical implications for biotechnology and pharmaceuticals, where the efficient production of antibiotics and other therapeutics is critical. Through her leadership at the Institute of Integrative Biology of the Cell (I2BC), Dr. Virolle has significantly advanced our understanding of microbial metabolism and its applications in industrial microbiology.

Conclusion:

Dr. Marie-Joëlle Virolle is a highly suitable candidate for the Research for Lifetime achievement Award. Her extensive research experience, leadership in scientific collaborations, successful acquisition of research funding, and editorial contributions make her an outstanding contender. With minor improvements in public outreach and interdisciplinary research, her profile could be further enhanced, solidifying her position as a leading researcher in her field.

📚Publications to Noted

  • Title: “Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain”
    Authors: Lejeune, C., Abreu, S., Guérard, F., Gakière, B., Virolle, M.-J.
    Journal: Microbial Biotechnology
    Year: 2024
    Citations: 0
  • Title: “The stringent response is strongly activated in the antibiotic-producing strain, Streptomyces coelicolor
    Authors: Lejeune, C., Cornu, D., Sago, L., Redeker, V., Virolle, M.-J.
    Journal: Research in Microbiology
    Year: 2024
    Citations: 1
  • Title: “The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains Streptomyces coelicolor and Streptomyces lividans
    Authors: Bi, Y., An, H., Chi, Z., Virolle, M.-J., Xu, D.
    Journal: Frontiers in Microbiology
    Year: 2024
    Citations: 0
  • Title: “Genome Analysis of a Variant of Streptomyces coelicolor M145 with High Lipid Content and Poor Ability to Synthetize Antibiotics”
    Authors: Dulermo, T., Lejeune, C., Aybeke, E., Leblond, P., Virolle, M.-J.
    Journal: Microorganisms
    Year: 2023
    Citations: 1
  • Title: “Metabolic adjustments in response to ATP spilling by the small DX protein in a Streptomyces strain”
    Authors: Apel, C., Levasseur, M., Lejeune, C., Chaput, J., Virolle, M.-J.
    Journal: Frontiers in Cell and Developmental Biology
    Year: 2023
    Citations: 3
  • Title: “Crystal structures of free and ligand-bound forms of the TetR/AcrR-like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism”
    Authors: Werten, S., Waack, P., Palm, G.J., Virolle, M.-J., Hinrichs, W.
    Journal: FEBS Journal
    Year: 2023
    Citations: 4
  • Title: “Comparative Proteomic Analysis of Transcriptional and Regulatory Proteins Abundances in S. lividans and S. coelicolor Suggests a Link between Various Stresses and Antibiotic Production”
    Authors: Clara, L., David, C., Laila, S., Virginie, R., Marie-Joelle, V.
    Journal: International Journal of Molecular Sciences
    Year: 2022
    Citations: 6
  • Title: “The Generation of an Artificial ATP Deficit Triggers Antibiotic Production in Streptomyces lividans
    Authors: Seghezzi, N., Darbon, E., Martel, C., Esnault, C., Virolle, M.-J.
    Journal: Antibiotics
    Year: 2022
    Citations: 5
  • Title: “A Proteomic Analysis Indicates That Oxidative Stress Is the Common Feature Triggering Antibiotic Production in Streptomyces coelicolor and in the pptA Mutant of Streptomyces lividans
    Authors: Lejeune, C., Sago, L., Cornu, D., Redeker, V., Virolle, M.-J.
    Journal: Frontiers in Microbiology
    Year: 2022
    Citations: 11
  • Title: “Isolation and characterization of phosphate solubilizing Streptomyces sp. endemic from sugar beet fields of the Beni-Mellal region in Morocco”
    Authors: Aallam, Y., Dhiba, D., Lemriss, S., Virolle, M.J., Hamdali, H.
    Journal: Microorganisms
    Year: 2021
    Citations: 17
Marie-Joelle VIROLLE | Antibiotics | Lifetime achievement Award

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