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Dr.FRANCESCOPADUANO|Biology|Lifetime achievement Award

RESEARCHER at MARRELLI HEALTH SRL, Italy.

Dr. Francesco Paduano is the Head of Medical and Molecular Genetics at MARRELLI HEALTH SRL and a researcher at TECNOLOGICA RESEARCH INSTITUTE in Crotone, Italy.He earned his PhD in Molecular Oncology, Experimental Immunology, and Development of Innovative Therapies from the University “Magna Graecia” of Catanzaro in 2012 and completed his specialization in Medical Genetics with highest honors from the same institution in 2022.Dr. Paduano holds five National Scientific Qualifications in fields including Biochemistry, Applied Biology, and Health Sciences.His research focuses on medical genetics, stem cell biology, and cancer research, leading to 58 peer-reviewed articles, four book chapters, and two patents.He serves as a Review Editor for journals such as Frontiers in Cell and Developmental Biology and Genes, and has received multiple awards, including the international GIANNI BONADONNA Prize for new drugs in oncology.

professional profiles📖

Education 🎓

Specialization in Medical Genetics (2022) – University Magna Græcia of Catanzaro, 70/70 cum laude.PhD in Molecular Oncology, Experimental Immunology & Innovative Therapies (2012) – University Magna Græcia of Catanzaro.State Exam for Biologist Profession (2010) – University of Calabria.Master in Bioinformatics (2006) – University of Milano-Bicocca.Bachelor’s Degree in Biological Sciences (Biomolecular Pathway) (2003) – University of Calabria, 110/110.Scientific High School Diploma (1995) – Liceo Scientifico E. Majorana, Cetraro.

work Experience💼

Head of Medical and Molecular Genetics Section at Marrelli Health SRL (2022–present).Researcher at University of Naples Federico II (2023) – Conducted genetic analyses for postnatal molecular diagnostics in osteogenesis imperfecta.Senior Researcher at Calabrodental S.R.L. (2015–present).Researcher in Oncological and Regenerative Medicine Projects at institutions such as the Italian National Institute for Cancer Research and University Magna Græcia.

Research Focus

Genetic predisposition to hereditary cancers, focusing on BRCA1, BRCA2, TP53.Development of bioactive prostheses and regenerative medicine applications.Analysis of genetic variants in rare diseases.Stem cell research in dental and orthopedic applications.Oncological research, including the role of PTPRJ as a tumor suppressor.

Skills

Next Generation Sequencing (NGS) for genomic panels.Bioinformatics for molecular diagnostics.Cell culture techniques, including 3D organoids.Genetic analysis and molecular diagnostics for rare diseases.Western Blot, PCR, qPCR, and gene expression analysis.Development of biomedical devices and biomaterials.Apoptosis and cell proliferation assays for drug testin.

Awards & Recognitions

Gianni Bonadonna Prize for new drugs in oncology (2013).SIE National Award (2017) for research in endodontic regeneration.Senior Robert Frank Award (2017) for stem cell research in neurodegenerative diseases.TAOBUK da Vinci Award (2022) for innovations in predictive medicine for Parkinson’s disease.

📚Publications to Noted

  • Tatullo, M., Marrelli, M., & Paduano, F. (2015). The regenerative medicine in oral and maxillofacial surgery: the most important innovations in the clinical application of mesenchymal stem cells. International Journal of Medical Sciences, 12(1), 72-77.

  • Paduano, F., Marrelli, M., White, L. J., Shakesheff, K. M., & Tatullo, M. (2016). Odontogenic differentiation of human dental pulp stem cells on hydrogel scaffolds derived from decellularized bone extracellular matrix and collagen type I. PLOS One, 11(2), e0148225.

  • Caruana, A., Savina, D., Macedo, J. P., & Soares, S. C. (2019). From platelet-rich plasma to advanced platelet-rich fibrin: biological achievements and clinical advances in modern surgery. European Journal of Dentistry, 13(2), 280-286.

  • Folini, M., Brambilla, C., Villa, R., Gandellini, P., Vignati, S., Paduano, F., … & Zaffaroni, N. (2005). Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells. European Journal of Cancer, 41(4), 624-634.

  • Marrelli, M., Paduano, F., & Tatullo, M. (2013). Cells isolated from human periapical cysts express mesenchymal stem cell-like properties. International Journal of Biological Sciences, 9(10), 1070-1078.

  • Marrelli, M., Codispoti, B., Shelton, R. M., Scheven, B. A., Cooper, P. R., Tatullo, M., & Paduano, F. (2018). Dental pulp stem cell mechanoresponsiveness: effects of mechanical stimuli on dental pulp stem cell behavior. Frontiers in Physiology, 9, 1685.

  • Paduano, F., Marrelli, M., Amantea, M., Rengo, C., Rengo, S., Goldberg, M., & Tatullo, M. (2017). Adipose tissue as a strategic source of mesenchymal stem cells in bone regeneration: a topical review on the most promising craniomaxillofacial applications. International Journal of Molecular Sciences, 18(10), 2140.

  • Paduano, F., Villa, R., Pennati, M., Folini, M., Binda, M., Daidone, M. G., & Zaffaroni, N. (2006). Silencing of survivin gene by small interfering RNAs produces supra-additive growth suppression in combination with 17-allylamino-17-demethoxygeldanamycin in prostate cancer cells. Molecular Cancer Therapeutics, 5(1), 179-186.

  • Conclusion

    Based on his exceptional research, technological contributions, and academic impact, Dr. Paduano is highly suitable for a Lifetime Achievement Award in Medical Research and Biotechnology. His work in oncology, genetics, and regenerative medicine has significantly shaped the field, making him a deserving candidate for this prestigious recognition.

FRANCESCO PADUANO | Biology | Lifetime achievement Award

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